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Loss of virological control has been reported in HIV-infected patients taking orlistat concomitantly with antiretroviral drugs such as atazanavirritonavirtenofovir disoproxil fumarateemtricitabineand with the combinations lopinavir/ritonavir and emtricitabine/efavirenz/tenofovir disoproxil fumarateThe exact mechanism for this is unclearbut may include a drug-drug interaction that inhibits systemic absorption of the antiretroviral drugHIV RNA levels should be frequently monitored in patients who take XENICAL while being treated for HIV infectionIf there is a confirmed increase in HIV viral loadXENICAL should be discontinued.

Read all patient informationmedication guidesand instruction sheets provided to youAsk your doctor or pharmacist if you have any questions.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

If you also take levothyroxinesuch as Synthroiddo not take it within 4 hours before or 4 hours after you take Xenical.

In a multiple-dose study in 30 normal-weight subjectscoadministration of XENICAL and 40 grams of alcohole.gapproximately 3 glasses of winedid not result in alteration of alcohol pharmacokineticsorlistat pharmacodynamicsfecal fat excretionor systemic exposure to orlistat.

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doctor s advice should be taken while administering prescribed xenical medication to patients between the age of 12 and 18.