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Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended when administering ketoconazole concurrently.

Dragsted UBGerstoft JPedersen Cet alRandomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patientsthe MaxCmin1 TrialJournal of Infectious Diseases 2003;188(5635-642.

See Table 9 for steps to prevent or manage these possible and known significant drug interactionsincluding dosing recommendationsConsider the potential for drug interactions prior to and during CRIXIVAN therapyreview concomitant medications during CRIXIVAN therapyand monitor for the adverse reactions associated with the concomitant medications.

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