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Psychic derangements may appear when corticosteroids areusedThese may range from euphoriainsomniamood swingspersonality changesand severe depression to frank psychotic manifestationsExisting emotional instability or psychotic tendencies may also be aggravated by corticosteroids.

Aspirin should be used cautiously in conjunction with corticosteroids in patients with hypoprothrombinemia.

The lowest possible dose of corticosteroid should be used to control the condition being treatedA gradual reduction in dosage should be made when possible.

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