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Psychic derangements may appear when corticosteroids areusedThese may range from euphoriainsomniamood swingspersonality changesand severe depression to frank psychotic manifestationsExisting emotional instability or psychotic tendencies may also be aggravated by corticosteroids.

Aspirin should be used cautiously in conjunction with corticosteroids in patients with hypoprothrombinemia.

The lowest possible dose of corticosteroid should be used to control the condition being treatedA gradual reduction in dosage should be made when possible.

The use of Florinef AcetateFludrocortisone Acetate Tablets USPin patients with active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimenIf corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivityclose observation is necessary since reactivation of the disease may occurDuring prolonged corticosteroid therapy these patients should receive chemoprophylaxis.

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