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There is limited clinical experience with REVIA overdosage in humansIn one studysubjects who received 800 mg daily REVIA for up to one week showed no evidence of toxicity.

In some individuals the use of opioid antagonists has been associated with a change in baseline levels of some hypothalamicpituitaryadrenalor gonadal hormonesThe clinical significance of such changes is not fully understood.

Clinicians are reminded that there is no completely reliable method for determining whether a patient has had an adequate opioid-free periodA naloxone challenge test may be helpful if there is any question of occult opioid dependenceIf signs of opioid withdrawal are still observed following naloxone challengetreatment with REVIA should not be attemptedThe naloxone challenge can be repeated in 24 hours.

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