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The most common side effects of EVISTA are hot flashesleg crampsswelling of the feetanklesand legsflu syndromejoint painand sweatingHot flashes are more common during the first 6 months after starting treatment.

Raloxifene appears to act as an estrogen agonist in boneIt decreases bone resorption and bone turnoverincreases bone mineral densityBMDand decreases fracture incidencePreclinical data demonstrate that raloxifene is an estrogen antagonist in uterine and breast tissuesThese results are consistent with findings in clinical trialswhich suggest that EVISTA lacks estrogen-like effects on the uterus and breast tissue.

Any unexplained breast abnormality occurring during EVISTA therapy should be investigatedEVISTA does not eliminate the risk of breast cancersee Clinical Studies

Uterine fibroids are benignnon-canceroustumors in the wombuterusMost uterine fibroids do not cause symptomshoweverif the fibroid is large enough and in the right locationit may cause symptoms of pelvic painabnormal vaginal bleedingand pressure on the bladder or rectum.

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evista is a type of prescription medicine called a selective estrogen receptor modulator serm .