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Treatment of renal disease in hypertensive patients with Type 2 diabetes mellitus and incipient nephropathysee section 5.1

CommentsTherapy should be initiated at 2.5 mg in patients with a low systolic blood pressureless than or equal to 120 mm Hg and greater than 100 mmHgduring the first 3 days after the infarctIf prolonged hypotension occurssystolic blood pressure less than 90 mmHg for more than 1 hourtherapy should be withdrawn.

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Lisinopril belongs to a class of drugs known as ACE inhibitorsIt works by relaxing blood vessels so blood can flow more easily.

Following oral administration of lisinoprilpeak serum concentrations occur within about 7 hoursalthough there was a trend to a small delay in time taken to reach peak serum concentrations in acute myocardial infarction patientsBased on urinary recoverythe mean extent of absorption of lisinopril is approximately 25with interpatient variability of 6-60over the dose range studied5-80 mgThe absolute bioavailability is reduced approximately 16in patients with heart failureLisinopril absorption is not affected by the presence of food.

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