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Hepaticmainly via CYP3A4Tinidazolelike metronidazoleis significantly metabolized in humans prior to excretionTinidazole is partly metabolized by oxidationhydroxylation and conjugationTinidazole is the major drug-related constituent in plasma after human treatmentalong with a small amount of the 2-hydroxymethyl metabolite.

Simultaneous administration of tinidazole with drugs that induce liver microsomal enzymesi.eCYP3A4 inducers such as phenobarbitalrifampinphenytoinand fosphenytoina pro-drug of phenytoinmay accelerate the elimination of tinidazoledecreasing the plasma level of tinidazoleSimultaneous administration of drugs that inhibit the activity of liver microsomal enzymesi.eCYP3A4 inhibitors such as cimetidine and ketoconazolemay prolong the half-life and decrease the plasma clearance of tinidazoleincreasing the plasma concentrations of tinidazole.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofliver diseasekidney dialysiscertain blood disorderslow blood cell counts

Rare reported adverse reactions include bronchospasmdyspneacomaconfusiondepressionfurry tonguepharyngitis and reversible thrombocytopenia.

Clinical studies of tinidazole did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjectsIn generaldose selection for an elderly patient should be cautiousreflecting the greater frequency of decreased hepaticrenalor cardiac functionand of concomitant disease or other drug therapy.

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tinidazole is used in the treatment of bacterial infections caused by the protozoa bacteria.