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Colchicine can also be injected through the skin or administered intravenously.

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The course of treatment should end when symptoms are relieved or when a total of 6 mg12 tabletshas been taken.

This medication is also used to prevent attacks of pain in the abdomenchestor joints caused by a certain inherited diseasefamilial Mediterranean feverIt is thought to work by decreasing your body’s production of a certain proteinamyloid Athat builds up in people with familial Mediterranean fever.

Cholesterol drugssuch as atorvastatinfluvastatinlovastatinpravastatinsimvastatinfibratesor gemfibrozilIncreased side effects can include serious muscle damageYour doctor may reduce your dosage of colchicine to avoid thisDigoxinan antiarrhythmic drugIncreased side effects can include serious muscle damageYour doctor may reduce your dosage of colchicine to avoid thisHeart drugssuch as verapamil or diltiazemIncreased side effects can include stomach painconstipationdiarrheanauseaor vomitingYour doctor may reduce your dosage of colchicine to avoid these problems.

Musculoskeletalmyopathyelevated CPKmyotoniamuscle weaknessmuscle painrhabdomyolysis.

In a published study in healthy volunteers40 to 65of the total absorbed dose of colchicine1 mg administered orallywas recovered unchanged in urineEnterohepatic recirculation and biliary excretion are also believed to play a role in colchicine eliminationColchicine is a substrate of P-gp and P-gp efflux is postulated to play an important role in colchicine dispositionElimination half-life in humans was found to be 31 hrange 21.7 to 49.9 h

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