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400 mg initiallyfollowed by 200 mg if needed on the first dayThen200 mg twice daily as needed.
Advise patients to be alert for the symptoms of congestive heart failure including shortness of breathunexplained weight gainor edema and to contact their healthcare provider if such symptoms occursee WARNINGS AND PRECAUTIONS
Celecoxib is a white to off-white powder with a pKa of 11.1sulfonamide moietyCelecoxib is hydrophobiclog P is 3.5and is practically insoluble in aqueous media at physiological pH range.
Coadministration of CELEBREX with an aluminumand magnesium-containing antacids resulted in a reduction in plasma celecoxib concentrations with a decrease of 37in Cmax and 10in AUCCELEBREXat doses up to 200 mg twice dailycan be administered without regard to timing of mealsHigher doses400 mg twice dailyshould be administered with food to improve absorption.
Avoid the use of CELEBREX in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failureIf CELEBREX is used in patients with severe heart failuremonitor patients for signs of worsening heart failure.
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